From March 5 to 7, 2025, the global natural products industry turned its attention to Anaheim, USA, for the grand opening of the Natural Products Expo West. As the largest and most influential event in North America, the exhibition brought together industry leaders from across the globe, creating an exciting and dynamic atmosphere. Innovators showcased cutting-edge products and concepts, igniting inspiring exchanges.

Bonerge also actively participated, highlighting core products such as Fisetin, Urolithin A, Dihydroberberine, AKK, and S-equol, joining the global community in discussing future trends in the health and nutrition sector.

Expo Focus: GLP-1 Leading a New Industry Direction

This year, GLP-1 (Glucagon-like peptide-1) emerged as a major theme, capturing the attention of the nutrition and food sectors. Following the success of semaglutide in 2024, which sparked a new wave of weight loss trends, the industry's interest in GLP-1 has skyrocketed.

While pharmaceutical GLP-1 treatments like semaglutide show effective results for weight management and blood sugar regulation, they come with side effects such as nausea, vomiting, and diarrhea. This has created a pressing need for complementary GLP-1 nutrition products to mitigate these side effects.

Bonerge's Solution: AKK and Dihydroberberine

Bonerge has recognized this market demand, bringing innovative solutions to the table with AKK and Dihydroberberine.

AKK: A Booster for GLP-1 Secretion

Akkermansia muciniphila (AKK) is a bacterium naturally found in the human gut that plays a crucial role in maintaining gut wall health. Studies have shown that AKK secretes an 84kDa P9 protein, which directly binds to ICAM-2 in the intestine and induces GLP-1 secretion in a calcium-dependent manner.

Simply put, AKK is like a “GLP-1 secretion assistant” in the intestine. In turn, GLP-1 enhances insulin secretion and inhibits glucagon secretion in a glucose concentration-dependent manner, stabilizing blood glucose levels; at the same time, AKK also delays gastric emptying and reduces the amount of food intake through central appetite suppression, which contributes to the control of body weight, and it is a milder way of management than Western drugs.

Bonerge’s AKK Amuctive™ strain is derived from healthy breast milk （unlike other strains from feces）, preserving AKK's benefits while offering superior traits such as low toxicity, genetic stability, and resistance to high pH and bile salts. Furthermore, AKK Amuctive™ strain is inactivated by PROFORCARE® Heat-Inactivated Technology, which allows complete inactivation of AKK bacteria at lower temperatures and keeps the bacteria intact. The inactivated AKK bacteria retain high genetic stability and active ingredients and are more adaptable to the complex environment of the gastrointestinal tract.

At the expo, professionals showed great interest in AKK’s mechanism and its potential applications.

Dihydroberberine: A Multi-Effect Synergist Supporting GLP-1 Innovation

Dihydroberberine is the reduced form of berberine, which has better bioavailability and stronger biological activity than berberine. Dihydroberberine can be rapidly converted into berberine to play a role after entering the organism. As a popular GLP-1 agonist in the market, berberine can effectively promote the secretion of GLP-1, and its mechanism of action includes promoting the expression of glucagon mRNA and the proliferation of intestinal L-cells, thus increasing the secretion of GLP-1, with an obvious quantitative and effective relationship; secondly, berberine can also stimulate the secretion of GLP-1 by the activation of the bitter receptor, TAS2R38, which is expressed in the intestine, and thus stimulate the secretion of GLP-1 by intestinal L-cells. cells to secrete GLP-1

On the other hand, when insulin resistance exists in the body, the action of GLP-1 will be somewhat limited, and dihydroberberine allows GLP-1 to better exert its role in regulating blood glucose by improving insulin resistance. In addition, dihydroberberine has anti-inflammatory properties and can reduce inflammatory reactions, which may be helpful in alleviating the inflammation-related side effects that may be caused by western drugs such as simethicone.

Bonerge's dihydroberberine is a unique crystalline dihydroberberine raw material developed to address the limitations of ordinary dihydroberberberine, such as its tendency to absorb moisture, degrade easily, and its low density, which is unfavorable for production. The density of the crystal form of dihydroberberberine is higher than 0.6/ml, and it has excellent mobility, which greatly reduces the difficulty of operation and loss in the process of capsule filling and other production processes. Moreover, the crystalline dihydroberberine is more stable, does not absorb moisture and does not degrade.

During the exhibition, many customers showed great interest in the synergistic effect of dihydroberberberine and GLP-1, and believed that this combination is expected to bring new product solutions to the market.

During the exhibition, many customers showed great interest in the synergistic effect of dihydroberberberine and GLP-1,

and believed that this combination is expected to bring new product solutions to the market.

Other Star Products: Fisetin, Urolithin A, and S-Equol Draw Attention

Beyond AKK and Dihydroberberine, Bonerge’s Fisetin, Urolithin A, and S-equol also attracted significant interest at the expo.

Fisetin: Regulate Senescent Cells and Immune Enhancement

Fisetin, a natural Senolytic (senescent cell scavenger) ingredient that has been the focus of the Mayo Medical Center in recent years, is found in a wide variety of fruits and vegetables such as strawberries, persimmons, and yucca. It is a natural ingredient with strong antioxidant activity and senescent cell scavenging activity.

Studies show that Fisetin can reduce the formation of senescent cells and clear existing ones, decreasing inflammation caused by these cells. It also promotes skin health, stimulates hair growth, and supports emotional health. Bonerge's BeFisetin is the first Fisetin ingredient to receive SA-GRAS certification.

Urolithin A: A New Regulator of Cellular Circadian Rhythms

Urolithin A, a metabolite produced by gut bacteria from ellagic acid found in fruits like pomegranates, has been shown to regulate cellular circadian rhythms, improving sleep quality.

It works by modulating the gut barrier’s circadian rhythm and enhancing the amplitude of the Bmal1 protein, a key biological clock component. Unlike melatonin, which can cause drowsiness or dizziness, Urolithin A improves sleep without these side effects. Many clients at the expo reported improved sleep and daytime energy levels after taking Urolithin A.

S-Equol: A Safe Supplement for Menopausal Health

S-Equol, a natural metabolite produced by intestinal microorganisms as a substrate for soy isoflavones, is an extremely specific and highly selective estrogen receptor modulator. In terms of estrogen regulation, it exhibits a highly selective agonism for estrogen receptor β (ERβ), but has a low activation capacity and affinity for estrogen receptor α (ERα). As a result, S-equel, unlike conventional estrogens, does not induce strong proliferative effects in ERα-dominant tissues, which greatly reduces the risks associated with estrogenic effects.

Studies have shown that only 20-40% of the population is able to produce S-equel in their own bodies.The high affinity of S-equel to ERβ makes it a good potential for use in alleviating women's menopausal hot flashes, night sweats, insomnia and other problems, skin health, emotional and sleep health, and bone health.

During the exhibition, many companies focusing on women's health products showed great interest in estragole and discussed how to better apply it in women's nutritional supplements, skincare products and other products to provide women with better health solutions.

During the exhibition, many companies focusing on women's health products showed great interest in estragole and

discussed how to better apply it in women's nutritional supplements, skincare products and other products to provide women with better health solutions.

Conclusion

The Natural Products Expo West 2025 was not only an exhibition of innovative products but also an important platform for Bonerge to engage with industry leaders and exchange ideas.

Through showcasing core products like AKK, Dihydroberberine, Fisetin, Urolithin A, and S-equol, Bonerge demonstrated its research and development capabilities in the health and nutrition field. The expo opened up numerous collaboration opportunities and provided valuable market feedback.

Moving forward, Bonerge will continue to deepen its focus on the health and nutrition industry, optimizing its products based on the insights gained at the expo, and working with industry partners to drive the future of global health and nutrition products.