The 'Senolytic–Repair–Chi'
Theory for Cellular Renewal
What's StanYouth® CR3 ?
StanYouth CR3 is a patented compound formula developed for cell repair, inspired by the Traditional Chinese Medicine (TCM) 'Senolytic-Repair-Chi' theory, into a precise intervention strategy at the cellular scale.
Clinically Proven Oral Beauty Benefits
In a 56-day human clinical trial, CR3 delivered significantly superior skin improvements compared with L-ergothioneine alone.
Synergy Confirmed in Cellular Studies
Human dermal fibroblast data show remarkable synergistic effects from the CR3 complex.
Science-Driven Formulation Beyond L-Ergothioneine
Amid the L-ergothioneine hype, StanYouth® CR3 offers a breakthrough strategy that helps brands escape price and dosage wars.
Triple Cell Repair Mechanism
CR3 targets senescent cell clearance, circadian rhythm balance, and cellular defense and energy support to build a multi-dimensional anti-aging barrier.
About 'Senolytic–Repair–Chi'
The Huangdi Neijing states: "The sages did not regulate those already in chaos, but those not yet in chaos." This ‘prevention before occurrence’ concept forms the theoretical origin of 'Senolytic-Repair-Chi', viewing the body as a dynamically balanced system.
Through progressive three-stage intervention, it achieves the goal of ‘strengthening the body when disease-free and intervening when disease occurs’, aligning with the TCM principle of 'treating disease before it arises'.
● Senolytic Aims to clear pathological products, particularly senescent cells, hindering physiological functions in the body, laying the foundation for subsequent conditioning and repair.
● Repair Aims to restore function and rebuild the imbalanced internal environment of the body, re-establishing a balanced, stable operational framework.
● Chi Aims to supplement and nourish the essential vital energy and refined substances required by the body, consolidating the foundation and cultivating vitality and resilience.
Health Benefits
Skin
Anti-Aging
In 2024, a research team led by Professor Kento at Keio University reported that fisetin can selectively eliminate approximately 66% of senescent dermal fibroblasts. It also suppresses the secretion of senescence-associated secretory phenotype (SASP) factors, thereby improving skin condition and slowing the progression of skin aging.
Additionally, fisetin was shown to increase collagen density by 41.2%, helping reduce wrinkles, skin laxity, and other visible signs of aging.
Biogerontology, 25(1), 161-175.
Enhances Firmness
& Smoothness
Studies show that Urolithin A (UA) is a star player in healing. It supercharges blood vessel growth (critical for delivering wound-reviving nutrients/oxygen): lab tests show 5-20μM UA ramps up key cell activity, while in real wound models, it speeds vessel formation, collagen repair and overall healing (via targeting the PI3K/AKT pathway). UA is poised to transform how we treat stubborn wounds.
Front Pharmacol. 2022 Mar 14;13:806284.
Promotes collagen synthesis
Fisetin effectively suppresses MMP-1 and MMP-3, reducing matrix-degrading enzymes and protecting dermal collagen and elastic fibers from senescent cell–derived damage, helping maintain skin structural integrity.
J. Mol. Sci. 2023, 24, 17358.
Promotes an even skin tone
Studies show that EGT, in its thione form, reacts with dopaquinone through its thio-imidazole ring, acting as a reversible tyrosinase inhibitor.
Moreover, its inhibitory effect on tyrosinase is stronger than common agents such as kojic acid and arbutin, effectively reducing melanin production and supporting a more even skin tone.
Biochem Biophys Res Commun. 2023 Nov 19:682:163-173.
In 2024, a research team led by Professor Kento at Keio University reported that fisetin can selectively eliminate approximately 66% of senescent dermal fibroblasts. It also suppresses the secretion of senescence-associated secretory phenotype (SASP) factors, thereby improving skin condition and slowing the progression of skin aging.
Additionally, fisetin was shown to increase collagen density by 41.2%, helping reduce wrinkles, skin laxity, and other visible signs of aging.
Biogerontology, 25(1), 161-175.
Studies show that Urolithin A (UA) is a star player in healing. It supercharges blood vessel growth (critical for delivering wound-reviving nutrients/oxygen): lab tests show 5-20μM UA ramps up key cell activity, while in real wound models, it speeds vessel formation, collagen repair and overall healing (via targeting the PI3K/AKT pathway). UA is poised to transform how we treat stubborn wounds.
Front Pharmacol. 2022 Mar 14;13:806284.
Fisetin effectively suppresses MMP-1 and MMP-3, reducing matrix-degrading enzymes and protecting dermal collagen and elastic fibers from senescent cell–derived damage, helping maintain skin structural integrity.
J. Mol. Sci. 2023, 24, 17358.
Studies show that EGT, in its thione form, reacts with dopaquinone through its thio-imidazole ring, acting as a reversible tyrosinase inhibitor.
Moreover, its inhibitory effect on tyrosinase is stronger than common agents such as kojic acid and arbutin, effectively reducing melanin production and supporting a more even skin tone.
Biochem Biophys Res Commun. 2023 Nov 19:682:163-173.
Clinical Summary
The Combined Impact of StanYouth CR3 on Human Dermal Fibroblasts
Enrolled: Human dermal fibroblasts
Dosage / Treatment: CR3 complex vs individual components (Fisetin, Urolithin A, L‑Ergothioneine)
Trial Cycle: In vitro assays
Detection Indicators: Senescent cell clearance (SA‑β‑Gal), Senescence-associated gene expression (p16, p21), Inflammatory factors (IL‑6, IL‑8, IL‑11), ROS accumulation, Cell migration rate
Result: CR3 complex showed significant synergistic effects over single components: senescent cell clearance ~80% (double Fisetin alone), near-normal restoration of senescence-related gene expression, potent inhibition of pro-inflammatory and fibrotic factors, reduced ROS, and enhanced cell migration.
The Combined Impact of StanYouth CR3 on skin Health
Enrolled: Healthy women aged 40–60 years
Dosage: StanYouth® CR3 complex (56-day supplementation)
Control Group: L‑Ergothioneine
Trial Cycle: 56 days
Detection Indicators: Skin firmness (F4), Under-eye wrinkle area, Skin brightness (L*), Skin color (ITA), Trans-epidermal water loss (TEWL)
Result: Compared with L‑Ergothioneine, StanYouth® CR3 significantly improved skin firmness (+16.3%), reduced under-eye wrinkle area (‑11.28%), increased skin brightness (+1.4%) and fairness (+6.10%), and decreased TEWL (‑18.18%).
Available In
Tablets
Hard Capsule
Soft Capsule
Powders
Beverages
Gummies
Liquids
Quality Assurance
NON-GMO
ISO 9001
Gluten Free
BSE Free
Halal Certified
Kosher Certified
HACCP
Frequently asked questions
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