Be The Golden Standard
of Fisetin
What is BeFisetin® ?
As the first fisetin ingredient to obtain SA-GRAS certification, Befisetin® stands out with its top-tier quality specifications-truly "Be the Golden Standard of Fisetin"
SA-GRAS Certified Fisetin
With systematic toxicological verification and a sound quality system, Befisetin guarantees product qualityand safety.
100% Natural Derived
BeFisetin is a Cotinus coggygria extract, 100% naturally sourced -unlike synthetic fisetin on the market.
Exceptional Purity
Total flavonoids over 99%, fisetin content above 98%, and impurities strictly below 1%.
Patented Technology
BeFisetin is produced via a patented process, using only purified water and ethanol as solvents-environmentally friendly.
About Fisetin
Fisetin (3,7,3',4'-tetrahydroxyflavone) is a natural flavonoid found in fruits and vegetables, known for its antioxidant, anti-inflammatory, and senolytic (clearing senescent cells) properties, making it a promising compound for supporting healthy aging, cognitive function, and cellular health, though research is ongoing and clinical trials are developing.
Fisetin works by scavenging free radicals, protecting DNA, and influencing pathways related to aging and cell senescence.
Health Benefits
The King of Botanical
Senolytic
Fisetin has been found to have Senolytic potential since 2017 by Dr. Kirkland, with high safety and efficient clearance of senescent cells.
Among the 11 natural Senolytics, fisetin reached more than 68% activity in clearing senescent cells, which is much higher than star ingredients such as quercetin, resveratrol and turmeric.
Biology 2025,14,829
Delay Ovarian Aging &
Support Ovarian Health
Multiple studies report that fisetin can delay premature ovarian failure, improve polycystic ovary syndrome, and support ovarian health.
Fisetin is shown to alleviates ovarian oxidative stress in aged laying hens by regulating SIRT1 and NF-κB pathways, activates AKT and JNK pathways to balance energy metabolism, promote follicle development, and delay ovarian aging in poultry.
Antioxidants 2024, 13(12), 1432.
Cellular Anti-aging &
Immune Enhancement
Fisetin delivers notable effects in reducing senescent cell formation, supporting cellular anti-aging, and promoting diverse health benefits.
A study featured in the May 2025 issue of Aging Cell found that fisetin enhances muscle strength and alleviates weakness in older adults by curbing senescent cell formation in skeletal muscle, thereby supporting skeletal muscle health and immune wellness.
Aging Cell. 2025 Aug;24(8):e70114.
The Beauty from Within
Senescent cell accumulation in skin is a key driver of aging. Long-term senescent fibroblasts show halted proliferation, heightened proteolytic activity, and reduced ECM deposition, contributing to tissue decline.
Fisetin selectively clears about 66% of human senescent dermal fibroblasts, suppresses SASP factors, and reduces SA-β-gal–positive cells along with p16 and p53 expression, supporting healthier skin aging.
Biogerontology. 2024 Feb;25(1):161-175.
Fisetin has been found to have Senolytic potential since 2017 by Dr. Kirkland, with high safety and efficient clearance of senescent cells.
Among the 11 natural Senolytics, fisetin reached more than 68% activity in clearing senescent cells, which is much higher than star ingredients such as quercetin, resveratrol and turmeric.
Biology 2025,14,829
Multiple studies report that fisetin can delay premature ovarian failure, improve polycystic ovary syndrome, and support ovarian health.
Fisetin is shown to alleviates ovarian oxidative stress in aged laying hens by regulating SIRT1 and NF-κB pathways, activates AKT and JNK pathways to balance energy metabolism, promote follicle development, and delay ovarian aging in poultry.
Antioxidants 2024, 13(12), 1432.
Fisetin delivers notable effects in reducing senescent cell formation, supporting cellular anti-aging, and promoting diverse health benefits.
A study featured in the May 2025 issue of Aging Cell found that fisetin enhances muscle strength and alleviates weakness in older adults by curbing senescent cell formation in skeletal muscle, thereby supporting skeletal muscle health and immune wellness.
Aging Cell. 2025 Aug;24(8):e70114.
Senescent cell accumulation in skin is a key driver of aging. Long-term senescent fibroblasts show halted proliferation, heightened proteolytic activity, and reduced ECM deposition, contributing to tissue decline.
Fisetin selectively clears about 66% of human senescent dermal fibroblasts, suppresses SASP factors, and reduces SA-β-gal–positive cells along with p16 and p53 expression, supporting healthier skin aging.
Biogerontology. 2024 Feb;25(1):161-175.
Clinical Summary
The Impact of BeFisetin® Supplementation on Skin Health
Enrolled: healthy women aged 40-60 years
Dosage: 500mg BeFisetin Fisetin
Control Group: 500mg placebo
Trial Cycle: 56Days
Detection Indicators: Skin heme, Skin inflammation, Trans epidermal water loss, Wrinkle volume, Wrinkle photography, Skin elasticity, Skin firmness, Skin melanin, Skin color. etc.
Result: Compared with the control group, fisetin significantly improved the skin barrier function, skin elasticity and firmness, and reduced the wrinkle area in the subject population.
The lmpact of BeFisetin® supplementationon Sleep Quality
Enrolled: Recruitment in progress; healthy adults (ethics approved)
Control Group: Placebo
Trial Cycle: 12 weeks
Detection indicators: Multiple sleep-quality measures, NAD+ level, DNA methylation age, inflammatory markers, cortisol, and circadian-related aging biomarkers
Status: Ethics approved; recruitment in progress; completion expected in 2026
Safety and Effectivness of Quercetin & Dasatinib & Fisetin on Epigenetic Aging
Enrolled: Aging people aged 44-88 yeas
Dosage: 500 mg Fisetin, 500 mg Quercetin and 50 mg Dasatinib oral capsules on Monday, Tuesday, and Wednesday (3 days in a row) per month.
Control Group: N/A
Trial Cycle: 6 Months
Detection Indicators: Epigenetic Age Test, Examining Methylation changes
Result: The addition of Fisetin to the treatment resulted in non-significant increases in epigenetic age acceleration, suggesting a potential mitigating effect of Fisetin on the impact of Dasatinib & Quercetin on epigenetic aging.
DOI: 10.18632/aging.205581
The Impact of Fisetin Supplementation on Persistent Symptoms of Long COVID
Enrolled: Long COVID patients aged 38-67 years
Dosage: Fisetin (Unspecified Dose)
Control Group: N/A
Trial Cycle: Average 23.2 Months
Detection Indicators: A 25-question survey (1-10 Likert scale)
Result: Among the 44 patients treated with Fisetin, 64% (28 patients) reported that it was effective in relieving Long COVID symptoms. This response rate was higher than those for CoQ10 (55%), Ashwagandha (46%), Reishi mushroom (42%), and Nattokinase/Serrapeptase (56%).
DOI: 10.1177/21501319241258671
Available in
Tablets
Hard Capsule
Soft Capsule
Powders
Beverages
Gummies
Liquids
Recommended Formulation
StanYouth CR3
Skin Cellular Rejuvenation:
Fisetin clears senescent cells, urolithin A repairs cellular rhythm, and L-Ergothioneine strengthens internal defenses (patent has been applied).
Reishi Mushroom Extract
Bioavailability:
Reishi mushroom extract can improve the bioavailability of fisetin by 10.17 times (patent has been applied).
S-Equol
Ovarian Health:
Fisetin provides support for follicular development and ovarian reserve by AMPK/SIRT1 pathway, and s-equol modulates ovarian function via ERβ.
Quality Assurance
ISO 22000
NON-GMO
HACCP
Kosher Certified
Halal Certified
Gluten Free
BSE Free
Frequently asked questions
What is the recommended dosage of fisetin?
What clinical backing does BeFisetin have?
What is the most significant health benefit of fisetin?
There are some synthetic fisetin materials on the market. How does BeFisetin differentiate from them?
In which countries is fisetin currently approved for use?
What is the applicable dosage form range for fisetin?
What are the water solubility and bioavailability of fisetin?
What is the plant source of BeFisetin? Is it extracted from strawberries?
Recommend Products
RequestSample
Leave Word
Have further questions? Our friendly experts will get back to you within 24 hours to assist you further
+1(425)866-9043
sales@bonerge.com