100% Natural Fermented
L-Ergothionine
QinMito® Cosmetic
With exceptional stability, excellent water solubility, and potent antioxidant, anti-aging, and photoprotective benefits, L-EGT is widely used in skincare and oral beauty products to support skin health from the inside out.
Advanced Formulation Technology
Through liposomal encapsulation and oil-phase processing, transdermal absorption and stability are significantly enhanced, enabling the successful launch of a 10% oil-soluble L-EGT.
100% Natural Fermentation Process
Produced through a 100% natural yeast fermentation process.
Patented Production Technology
Including patents for an EgtD enzyme mutant and a sulfoxide synthase used in L-ergothionine production.
Exceptional Purity
HPLC-tested purity of QinMito L-ergothionine exceeds 99.99%.
About L-Ergothionine
L-Ergothioneine (EGT) is a naturally occurring, highly stable antioxidant amino acid found in foods like mushrooms. In skin health, it is uniquely transported into cells via a specific transporter, where it accumulates to provide long-lasting protection. Its primary mechanism involves neutralizing free radicals and shielding skin cells from oxidative damage caused by UV radiation and pollution, thereby helping to prevent photoaging and inflammation.
Clinically, L-Ergothioneine has been shown to improve skin hydration, reduce redness, and diminish the appearance of fine lines. It supports skin barrier function and enhances overall skin resilience against environmental stressors.
Health Benefits
Powerful Antioxidant & Skin Barrier Protection
EGT is able to accumulate in mitochondria and nucleus via the specific transporter OCTN1, enabling it to directly scavenge mitochondrial reactive oxygen species (ROS), support mitochondrial membrane integrity, and help maintain cellular energy production.
Moreover, EGT activates the KEAP1–NRF2 signaling pathway and downstream antioxidant defense genes (e.g. HO-1, NQO1, SOD, CAT), enhancing the skin’s resistance to oxidative stress, reducing inflammation, and ultimately helping to preserve the skin barrier under environmental and UV-induced stress.
Biochem Biophys Res Commun. 2024 Sep 24:726:150269; Protein Cell. 2023 Aug 10;15(3):191–206.
Delays Photoaging
Ergothioneine (EGT) absorbs ultraviolet light (peak ~257 nm), inhibits the formation of advanced glycation end-products (AGEs), and prevents their cross-linking with collagen. It also reduces MMP-1–mediated collagen breakdown while supporting type I collagen synthesis.
Additionally, EGT protects mitochondrial DNA from UV-induced damage, helping to reduce oxidative stress and ultimately slow the progression of skin photoaging.
Molecules 2023, 28(4), 1648
Soothes Skin & Reduces Inflammation
Studies show that EGT is strongly linked to RUNX1 regulation, enabling it to downregulate MAPK-driven inflammatory factors such as IL-33 and reduce keratinocyte inflammatory markers.
Moreover, by limiting ROS accumulation, EGT indirectly modulates p53/p63-mediated apoptosis and, through its interaction with RUNX1, supports keratinocyte and skin stem cell renewal, helping restore the skin barrier and improve atopic conditions.
Molecules. 2023 Feb 8;28(4):1648.
Promotes an even skin tone
Studies show that EGT, in its thione form, reacts with dopaquinone through its thio-imidazole ring, acting as a reversible tyrosinase inhibitor.
Moreover, its inhibitory effect on tyrosinase is stronger than common agents such as kojic acid and arbutin, effectively reducing melanin production and supporting a more even skin tone.
Biochem Biophys Res Commun. 2023 Nov 19:682:163-173.
EGT is able to accumulate in mitochondria and nucleus via the specific transporter OCTN1, enabling it to directly scavenge mitochondrial reactive oxygen species (ROS), support mitochondrial membrane integrity, and help maintain cellular energy production.
Moreover, EGT activates the KEAP1–NRF2 signaling pathway and downstream antioxidant defense genes (e.g. HO-1, NQO1, SOD, CAT), enhancing the skin’s resistance to oxidative stress, reducing inflammation, and ultimately helping to preserve the skin barrier under environmental and UV-induced stress.
Biochem Biophys Res Commun. 2024 Sep 24:726:150269; Protein Cell. 2023 Aug 10;15(3):191–206.
Ergothioneine (EGT) absorbs ultraviolet light (peak ~257 nm), inhibits the formation of advanced glycation end-products (AGEs), and prevents their cross-linking with collagen. It also reduces MMP-1–mediated collagen breakdown while supporting type I collagen synthesis.
Additionally, EGT protects mitochondrial DNA from UV-induced damage, helping to reduce oxidative stress and ultimately slow the progression of skin photoaging.
Molecules 2023, 28(4), 1648
Studies show that EGT is strongly linked to RUNX1 regulation, enabling it to downregulate MAPK-driven inflammatory factors such as IL-33 and reduce keratinocyte inflammatory markers.
Moreover, by limiting ROS accumulation, EGT indirectly modulates p53/p63-mediated apoptosis and, through its interaction with RUNX1, supports keratinocyte and skin stem cell renewal, helping restore the skin barrier and improve atopic conditions.
Molecules. 2023 Feb 8;28(4):1648.
Studies show that EGT, in its thione form, reacts with dopaquinone through its thio-imidazole ring, acting as a reversible tyrosinase inhibitor.
Moreover, its inhibitory effect on tyrosinase is stronger than common agents such as kojic acid and arbutin, effectively reducing melanin production and supporting a more even skin tone.
Biochem Biophys Res Commun. 2023 Nov 19:682:163-173.
Available in
Beauty from Within
Toner
Lotion
Cream
Facial Oil
Sheet Mask
Sunscreen
Recommended Formulation
StanYouth® CR3
Skin Cellular Rejuvenation:
Fisetin clears senescent cells, urolithin A repairs cellular rhythm, and L-Ergothioneine strengthens internal defenses (patent has been applied).
Pro-Xylane
Skin Anti-aging:
L-Ergothioneine can reduce the collagen degradation through MMP-1, while pro-xylane can promote the synthesis of collagen and tight connection of skin, making the skin tougher and more elastic.
Ectoin
Skin Care:
L-Ergothioneine can help skin barrier remodeling by anti-oxidation, and ectoin can enhance the hydration on the phospholipid membrane to improve the ability of withstanding extreme environments.
Quality Assurance
NON-GMO
ISO 9001
Gluten Free
BSE Free
Halal Certified
Kosher Certified
HACCP
ISO 22000
Frequently asked questions
What is the most significant health benefit of QinMito L-Ergothioneine?
Is QinMito L-Ergothioneine fermented or synthesized?
What is the recommended daily dosage for L-Ergothioneine?
What is the purity of QinMito L-Ergothioneine ?
Does QinMito L-Ergothioneine have Kosher, Halal, or other certifications?
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