About

Bonerge is an innovative manufacturer that provides comprehensive turn-key solutions within the fields of the Nutraceutical and Cosmeceutical ingredients industries.

Our core focus lies in the discovery and development of ingredients for Ageless Energy, Healthspan and Longevity.

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About

Bonerge is an innovative manufacturer that provides comprehensive turn-key solutions within the fields of the Nutraceutical and Cosmeceutical ingredients industries.

Our core focus lies in the discovery and development of ingredients for Ageless Energy, Healthspan and Longevity.

Contact
About

Bonerge is an innovative manufacturer that provides comprehensive turn-key solutions within the fields of the Nutraceutical and Cosmeceutical ingredients industries.

Our core focus lies in the discovery and development of ingredients for Ageless Energy, Healthspan and Longevity.

Contact
Bonerge

Oil Soluble Pro-Xylane

Utilizing patented emulsification technology, this oil-based Pro-Xylane solution offers a clean, transparent, and stable matrix with a content exceeding 10%, ideal for advanced skincare formulations.

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Bonerge

Water Soluble Fisetin

Fully soluble in water, this clear and transparent Fisetin solution contains 5%–10% active ingredient with customizable concentration options for versatile product applications.

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Bonerge

Urolithin A High-Bioavailability Softgel

Featuring a uniform and easily dispersible core matrix, this softgel formulation enhances the bioavailability of Urolithin A by 5 times, offering optimized efficacy and user experience.

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Fisetin Benefits for Ovarian Health: Supporting POI, PCOS and Menopause

Fisetin Benefits for Ovarian Health: Supporting POI, PCOS and Menopause

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Fisetin Benefits for Ovarian Health: Supporting POI, PCOS and Menopause

Fisetin Benefits for Ovarian Health: Supporting POI, PCOS and Menopause

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Fisetin Benefits for Ovarian Health: Supporting POI, PCOS and Menopause

Fisetin Benefits for Ovarian Health: Supporting POI, PCOS and Menopause

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At Bonerge, we believe that meaningful progress is born from collaboration. We are committed to building open, trusting, and long-term partnerships that drive innovation and create shared value.

At Bonerge, we believe that meaningful progress is born from collaboration. We are committed to building open, trusting, and long-term partnerships that drive innovation and create shared value.

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At Bonerge, we believe that meaningful progress is born from collaboration. We are committed to building open, trusting, and long-term partnerships that drive innovation and create shared value.

At Bonerge, we believe that meaningful progress is born from collaboration. We are committed to building open, trusting, and long-term partnerships that drive innovation and create shared value.

Talk to Our Team
Stand by Youth with Ultra Pure Urolithin A
Stand by Youth with Ultra Pure Urolithin A

Stand by Youth with
Ultra Pure Urolithin A

What is StanYouth® ?

Driven by >99% purity and versatile multi-format compatibility, StanYouth is enabling global brands to pioneer the next generation of anti-aging, beauty, and sleep-rhythm innovations.

What is StanYouth® ?
Clean and Safety

Clean and Safety

Unlike market UA with varying colors and unseen solution impurities, StanYouth delivers a uniform light-yellow powder and clear solutions—evidence of its high purity.

>99% Purity

>99% Purity

Purity >99% verified by HPLC/HNMR with batch consistency ensured by a calibrated in-house WRS.

Patent-Pending Process

Patent-Pending Process

Innovative and proprietary technology.

Pioneering Scale

Pioneering Scale

Among the first globally for large-scale production.

About Urolithin A
Benefits
Clinical Summary
Application
Why Choose
Quality Assurance
Q & A
Recommend Products
About Urolithin A

About Urolithin A

Urolithin A ( UA ) is a natural postbiotic compound produced by gut bacteria from precursors found in certain foods (pomegranates, walnuts, etc. ), and it has attracted research interest for its potential anti-aging and health benefits, particularly for cellular health, sleep health.

Only about 40% of people can naturally convert dietary precursors into meaningful levels of urolithin A, making direct supplementation an option for others to achieve beneficial levels.

About Urolithin A

Health Benefits

Regulating Circadian Rhythms & Improving Sleep Quality

Regulating Circadian Rhythms & Improving Sleep Quality

New research shows that Urolithin A may help regulate circadian rhythm and mitigate disruptions caused by modern lifestyles—such as shift work or irregular sleep—through two key mechanisms:

⦁ It restores clock gene rhythm in gut cells and reduces inflammation and circadian disruption induced by cytokines.

⦁ It enhances Bmal1 expression in aging cells by stabilizing SIRT1, increasing its deacetylase activity, and promoting PER2 degradation.

Nutrients 2025, 17, 20.

Reducing Fatigue 
from Sleep Deprivation

Reducing Fatigue
from Sleep Deprivation

Urolithin A effectively alleviates exercise impairment caused by sleep deprivation (SD) in mice, significantly enhancing motor performance and reducing fatigue.

After supplementation with Urolithin A, sleep-deprived mice showed a 55.6% increase in grip strength, significantly surpassing the effect of caffeine. Furthermore, mice treated with Urolithin A exhibited around 100% longer time to fatigue, suggesting that regulating cellular rhythms may enhance energy and vitality.

Mol Nutr Food Res. 2024 Apr;68(7):e2300599.

Enhances NAD+/NADH Recycling & Boosts Cellular Energy

Enhances NAD+/NADH Recycling & Boosts Cellular Energy

NAD+ is an essential coenzyme critical for cellular metabolism and energy homeostasis. Studies demonstrate that Urolithin A increases NAD+ significantly in vivo. It raises NAD+ levels by ~50% in mice—matching the effect of a 5x higher dose of NR.

Unlike external supplements, it enhances the body’s own NAD+ production by activating the SIRT1-NAMPT pathway to enhance endogenous synthesis. This "metabolic reprogramming" mechanism provides a theoretical basis for the long-term safety of this intervention.

Sci Rep. 2020 Nov 19;10(1):20184.

Improves Ovarian Function & Fertility

Improves Ovarian Function & Fertility

The ovarian reserve, a finite supply of eggs formed at birth, is crucial for fertility. It can be depleted early by overactivation or chemotherapy, leading to infertility and menopause.

Urolithin A (UA) protects this reserve by blocking PI3K/Akt signaling to maintain follicle dormancy. It reduces growing follicles and slows depletion. UA also counters chemotherapy damage by reducing DNA damage and preventing cell death, making it a promising treatment to support fertility.

Biology 2025,14,829

Regulating Circadian Rhythms & Improving Sleep Quality

New research shows that Urolithin A may help regulate circadian rhythm and mitigate disruptions caused by modern lifestyles—such as shift work or irregular sleep—through two key mechanisms:

⦁ It restores clock gene rhythm in gut cells and reduces inflammation and circadian disruption induced by cytokines.

⦁ It enhances Bmal1 expression in aging cells by stabilizing SIRT1, increasing its deacetylase activity, and promoting PER2 degradation.

Nutrients 2025, 17, 20.

Reducing Fatigue 
from Sleep Deprivation

Urolithin A effectively alleviates exercise impairment caused by sleep deprivation (SD) in mice, significantly enhancing motor performance and reducing fatigue.

After supplementation with Urolithin A, sleep-deprived mice showed a 55.6% increase in grip strength, significantly surpassing the effect of caffeine. Furthermore, mice treated with Urolithin A exhibited around 100% longer time to fatigue, suggesting that regulating cellular rhythms may enhance energy and vitality.

Mol Nutr Food Res. 2024 Apr;68(7):e2300599.

Enhances NAD+/NADH Recycling & Boosts Cellular Energy

NAD+ is an essential coenzyme critical for cellular metabolism and energy homeostasis. Studies demonstrate that Urolithin A increases NAD+ significantly in vivo. It raises NAD+ levels by ~50% in mice—matching the effect of a 5x higher dose of NR.

Unlike external supplements, it enhances the body’s own NAD+ production by activating the SIRT1-NAMPT pathway to enhance endogenous synthesis. This "metabolic reprogramming" mechanism provides a theoretical basis for the long-term safety of this intervention.

Sci Rep. 2020 Nov 19;10(1):20184.

Improves Ovarian Function & Fertility

The ovarian reserve, a finite supply of eggs formed at birth, is crucial for fertility. It can be depleted early by overactivation or chemotherapy, leading to infertility and menopause.

Urolithin A (UA) protects this reserve by blocking PI3K/Akt signaling to maintain follicle dormancy. It reduces growing follicles and slows depletion. UA also counters chemotherapy damage by reducing DNA damage and preventing cell death, making it a promising treatment to support fertility.

Biology 2025,14,829

Clinical Summary

Oral Beauty

Sleep Health

Oral Beauty

The Impact of StanYouth® Supplementation on Skin Health

Enrolled: healthy women aged 40-60 years

Dosage: 500mg StanYouth® Urolithin A

Control Group: 500mg placebo

Trial Cycle: 56 Days

Detection Indicators: Skin heme, Skin inflammation, Trans epidermal water loss, Wrinkle volume, Wrinkle photography, Skin elasticity, Skin firmness, Skin melanin, Skin color. etc.

Result: Compared with the control group, UA significantly improved the skin barrier function, skin elasticity and firmness, and reduced the wrinkle area in the subject population.

Contact Us for Clinical Results
Sleep Health

The Impact of StanYouth® Supplementation on Sleep Quality

Enrolled: Recruitment in progress; healthy adults (ethics approved)

Control Group: Placebo

Trial Cycle: 12 weeks

Detection Indicators: Multiple sleep-quality measures, NAD+ level, DNA methylation age, inflammatory markers, cortisol, and circadian-related aging biomarkers

Status: Ethics approved; recruitment in progress; completion expected in 2026

Contact Us for Clinical Results

Available in

Tablets

Tablets

Hard Capsule

Hard Capsule

Soft Capsule

Soft Capsule

Powders

Powders

Beverages

Beverages

Gummies

Gummies

Liquids

Liquids

Recommended Formulation

StanYouth CR3
Fisetin
CoQ10
StanYouth CR3
StanYouth CR3

StanYouth CR3

Skin Cellular Rejuvenation:
Fisetin clears senescent cells, urolithin A repairs cellular rhythm, and L-ergothioneine strengthens internal defenses (patent has been applied).

Fisetin
Fisetin

Fisetin

Sleep Rhythm:
Urolithin A can improve the circadian rhythm disorder by regulating rhythm genes, and fisetin can clear senescent cells to reduce oxidative stress and inflammation, indirectly providing a great state for sleep.

CoQ10
CoQ10

CoQ10

NAD+ Support:
Urolithin A can active the SIRT1-NAMPT pathway, and CoQ10 can maintain the operation of mitochondria to promote the production of NAD+.

Quality Assurance

NON-GMO

NON-GMO

ISO-9001

ISO-9001

Gluten-Free

Gluten-Free

BSE-Free

BSE-Free

Halal Certified

Halal Certified

Kosher Certified

Kosher Certified

HACCP

HACCP

ISO-22000

ISO-22000

Frequently asked questions

Frequently asked questions

Does StanYouth Urolithin A have clinical data?

StanYouth currently has one completed clinical trial (in the area of skin health) and one ongoing clinical trial (focusing on aging and sleep quality).

What is the production process for StanYouth Urolithin A? Is it extracted?

StanYouth Urolithin A is produced via chemical synthesis. Urolithin A is a metabolite of natural compounds like ellagic acid and is not present as such in plants. Claims of "extracted" Urolithin A on the market are incorrect.

In which countries is Urolithin A currently available for use?

Urolithin A is currently marketed and sold as a dietary supplement in countries such as the United States and Canada.

What is the water solubility of Urolithin A?

Urolithin A has poor water solubility. To address this, Bonerge has developed a water-soluble Urolithin A with a Urolithin A content of 20%-30%. This formulation is stable and significantly enhances bioavailability.

What are the flowability of StanYouth Urolithin A?

The bulk density of most Urolithin A raw materials on the market is around 0.4 g/ml, with generally poor flowability. Through a specialized process, StanYouth has increased the bulk density to approximately 0.6 g/ml, significantly improving its flowability and production-friendliness.

How stable is StanYouth Urolithin A?

Urolithin A exhibits excellent stability under proper storage conditions, with a shelf life of 3 years.

What certifications does StanYouth currently hold?

StanYouth is manufactured in a GMP-compliant facility and holds certifications including FSSC 22000, Kosher, and Halal.
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