Be The Golden Standard
of Fisetin
BeFisetin® Cosmetic
BeFisetin® Cosmetic Fisetin— the first SA-GRAS approved fisetin ingredient, now advancing toward official cosmetic raw-material registration.
Regulatory Breakthrough
BeFisetin has submitted a China cosmetic new ingredient application and is positioned as the first fisetin approved for skin-protective use in cosmetics.
Advanced Solubility Innovation
Through our proprietary technology platform, both oil-soluble and water-soluble fisetin have been successfully developed, for diverse formulations.
Exceptional Purity
Total flavonoids over 99%, fisetin content above 98%, and impurities strictly below 1%, ensuring product safety.
Patented Technology
BeFisetin is produced via a patented process, using only purified water and ethanol as solvents-environmentally friendly.
About Fisetin
Fisetin is a naturally occurring flavonoid, a type of plant polyphenol found in various fruits and vegetables such as strawberries, apples, persimmons, and onions. In recent years, it has gained significant attention in dermatology and skincare for its potent biological activities and promising benefits for skin health.
Fisetin targets several fundamental processes of skin aging and damage. Its unique combination of antioxidant, anti-inflammatory, and particularly senolytic properties makes it a promising ingredient in advanced skincare formulations aimed at promoting longevity, resilience, and a youthful appearance of the skin.
Health Benefits
Clear Senescent Skin Cells
& Delay Skin Aging
In 2024, Professor Kento’s team at Keio University in Japan discovered that fisetin can selectively eliminate approximately 66% of senescent dermal fibroblasts and suppress the secretion of the senescence-associated secretory phenotype (SASP). These effects help improve overall skin condition and slow down the skin-aging process.
At the same time, fisetin was shown to increase collagen density by 41.2%, improving visible signs of aging such as wrinkles and skin laxity.
Biogerontology. 2024 Feb;25(1):161-175.
Promotes collagen synthesis
& Firms Wrinkles
Fisetin effectively suppresses MMP-1 and MMP-3, reducing matrix-degrading enzymes and protecting dermal collagen and elastic fibers from senescent cell–derived damage, helping maintain skin structural integrity.
J. Mol. Sci. 2023, 24, 17358.
Strong Antioxidant &
Mitigates Photo Damage
As a potent antioxidant, fisetin exhibits strong anti-inflammatory activity and can directly neutralize ROS in the dermis, such as superoxide anions and hydroxyl radicals.
It also effectively inhibits UV-induced ROS production, reducing DNA damage in skin cells and alleviating sun-induced inflammation, fine lines, and skin damage.
J. Mol. Sci. 2023, 24, 17358.
Improves chronic skin inflammation
Fisetin significantly suppresses the expression of inflammatory mediators (NO, PGE2, IL-1β, IL-6) and key enzymes (iNOS, COX-2), while blocking NF-κB activation and inhibiting mTOR activity.
It shows promising effects in improving various skin inflammatory conditions, including atopic dermatitis, urticaria, and psoriasis-like skin inflammation.
Front Immunol. 2023 Jan 18;13:1075804.
In 2024, Professor Kento’s team at Keio University in Japan discovered that fisetin can selectively eliminate approximately 66% of senescent dermal fibroblasts and suppress the secretion of the senescence-associated secretory phenotype (SASP). These effects help improve overall skin condition and slow down the skin-aging process.
At the same time, fisetin was shown to increase collagen density by 41.2%, improving visible signs of aging such as wrinkles and skin laxity.
Biogerontology. 2024 Feb;25(1):161-175.
Fisetin effectively suppresses MMP-1 and MMP-3, reducing matrix-degrading enzymes and protecting dermal collagen and elastic fibers from senescent cell–derived damage, helping maintain skin structural integrity.
J. Mol. Sci. 2023, 24, 17358.
As a potent antioxidant, fisetin exhibits strong anti-inflammatory activity and can directly neutralize ROS in the dermis, such as superoxide anions and hydroxyl radicals.
It also effectively inhibits UV-induced ROS production, reducing DNA damage in skin cells and alleviating sun-induced inflammation, fine lines, and skin damage.
J. Mol. Sci. 2023, 24, 17358.
Fisetin significantly suppresses the expression of inflammatory mediators (NO, PGE2, IL-1β, IL-6) and key enzymes (iNOS, COX-2), while blocking NF-κB activation and inhibiting mTOR activity.
It shows promising effects in improving various skin inflammatory conditions, including atopic dermatitis, urticaria, and psoriasis-like skin inflammation.
Front Immunol. 2023 Jan 18;13:1075804.
Available in
Beauty from Within
Toner
Lotion
Cream
Facial Oil
Sheet Mask
Sunscreen
Recommended Formulation
StanYouth CR3
Skin Cellular Rejuvenation:
Fisetin clears senescent cells, urolithin A repairs cellular rhythm, and L-Ergothioneine strengthens internal defenses (patent has been applied).
Vitamin C
Antioxidant Network:
Forms a synergistic antioxidant network, recycling each other to provide enhanced protection against photoaging and oxidative stress.
Peptide
Collagen Synthesis:
Stimulates collagen production, directly complementing Fisetin's role in protecting existing collagen for enhanced anti-aging.
Quality Assurance
NON-GMO
ISO 9001
Gluten Free
BSE Free
Halal Certified
Kosher Certified
HACCP
ISO 22000
Frequently Asked Questions
What is the plant source of BeFisetin? Is it extracted from strawberries?
What clinical backing does BeFisetin have?
In which countries is fisetin currently approved for use?
There are some synthetic fisetin materials on the market. How does BeFisetin differentiate from them?
What is the most significant health benefit of fisetin?
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