Stand by Youth with Ultra Pure Urolithin A
StanYouth® Cosmetic
On August 26, 2025, NMPA approval of StanYouth® Urolithin A marked a milestone as the cosmetic Urolithin A ingredient connecting circadian rhythm regulation with visible skin health and longevity benefits.
Regulatory Milestone
NMPA approval positions StanYouth Urolithin A ingredient authorized for cosmetic applications.
Clinically Validated Beauty from Within
A nutricosmetic clinical study shows that daily intake of 500 mg StanYouth® improves skin barrier function, elasticity, and wrinkle appearance.
Advanced Delivery Technology
Liposomal encapsulation and oil-phase processing significantly enhance transdermal absorption and formulation stability.
>99% Purity
Verified by an Italian independent third-party laboratory, StanYouth Urolithin A exceeds 99% purity, ensuring product integrity and safety.
About Urolithin A
Urolithin A is a bioactive compound derived from foods like pomegranates. In skin health, it primarily functions by activating cellular repair pathways, notably supporting proteins like SIRT1 that help protect and maintain DNA integrity. This contributes to skin cell resilience against environmental stressors.
Furthermore, Urolithin A helps synchronize the skin’s circadian rhythm, enhancing its natural nighttime repair process. Clinical observations indicate improved skin smoothness, reduced visible signs of daily stress, and better overall skin vitality through these mechanisms.
Health Benefits
Regulate Skin's Circadian Rhythm
Skin cell biological clocks are crucial for regulating repair, regeneration, and barrier function. First identified in 2000 by American biologist Susanna B., the clock genes CLOCK and PER1 were shown to drive daily physiological cycles. Disruption of this rhythm increases water loss, impairs barrier function, and accelerates collagen breakdown.
Studies show that Urolithin A can restore and strengthen circadian rhythms: it boosts the amplitude of luciferase oscillations in aged cells by up to fourfold, normalizes clock gene expression such as BMAL1 and PER2 in intestinal epithelial cells, and modulates the central clock system in the suprachiasmatic nucleus (SCN) of mice.
Nutrients. 2024 Jul 13;16(14):2263; Nutrients. 2024 Dec 25;17(1):20.
Boost
Collagen Synthesis
Studies show that Urolithin A (UA) treatment significantly enhances collagen deposition and remodeling in wounds. Masson’s trichrome staining and collagen I/III immunohistochemistry showed stronger, regularly arranged collagen fibers in UA-treated groups compared to controls.
Moreover, UA accelerates re-epithelialization, as indicated by thicker neonatal epidermis and increased cytokeratin expression, suggesting faster wound closure and improved skin regeneration.
Front Pharmacol. 2022 Mar 14;13:806284.
Enhance
Skin Cell Renewal
In a full-thickness skin wound model, Urolithin A (UA)-treated wounds healed faster than controls. By day 7, the UA group achieved nearly 70% wound closure compared to 50% in the control group, and by day 21, wounds in the UA group were almost fully closed.
Mechanistic studies revealed that UA binds directly to PI3K and AKT, inhibiting their phosphorylation and regulating the PI3K/AKT signaling pathway. This promotes angiogenesis and collagen deposition, supporting faster wound healing and enhanced skin cell renewal.
Front Pharmacol. 2022 Mar 14;13:806284.
Refine
Wrinkle Depth
Studies show that Urolithin A (UA) is effective in improving features of skin aging, particularly by reducing wrinkles.
Clinical trials in humans demonstrated that topical application of 1% UA in various formulations (day cream, night cream, and serum) significantly decreased facial wrinkle depth in middle-aged and older participants. Moreover, UA enhanced skin hydration, reduced inflammation, and contributed to overall improvements in skin aging.
Front Pharmacol. 2022 Mar 14;13:806284.
Skin cell biological clocks are crucial for regulating repair, regeneration, and barrier function. First identified in 2000 by American biologist Susanna B., the clock genes CLOCK and PER1 were shown to drive daily physiological cycles. Disruption of this rhythm increases water loss, impairs barrier function, and accelerates collagen breakdown.
Studies show that Urolithin A can restore and strengthen circadian rhythms: it boosts the amplitude of luciferase oscillations in aged cells by up to fourfold, normalizes clock gene expression such as BMAL1 and PER2 in intestinal epithelial cells, and modulates the central clock system in the suprachiasmatic nucleus (SCN) of mice.
Nutrients. 2024 Jul 13;16(14):2263; Nutrients. 2024 Dec 25;17(1):20.
Studies show that Urolithin A (UA) treatment significantly enhances collagen deposition and remodeling in wounds. Masson’s trichrome staining and collagen I/III immunohistochemistry showed stronger, regularly arranged collagen fibers in UA-treated groups compared to controls.
Moreover, UA accelerates re-epithelialization, as indicated by thicker neonatal epidermis and increased cytokeratin expression, suggesting faster wound closure and improved skin regeneration.
Front Pharmacol. 2022 Mar 14;13:806284.
In a full-thickness skin wound model, Urolithin A (UA)-treated wounds healed faster than controls. By day 7, the UA group achieved nearly 70% wound closure compared to 50% in the control group, and by day 21, wounds in the UA group were almost fully closed.
Mechanistic studies revealed that UA binds directly to PI3K and AKT, inhibiting their phosphorylation and regulating the PI3K/AKT signaling pathway. This promotes angiogenesis and collagen deposition, supporting faster wound healing and enhanced skin cell renewal.
Front Pharmacol. 2022 Mar 14;13:806284.
Studies show that Urolithin A (UA) is effective in improving features of skin aging, particularly by reducing wrinkles.
Clinical trials in humans demonstrated that topical application of 1% UA in various formulations (day cream, night cream, and serum) significantly decreased facial wrinkle depth in middle-aged and older participants. Moreover, UA enhanced skin hydration, reduced inflammation, and contributed to overall improvements in skin aging.
Front Pharmacol. 2022 Mar 14;13:806284.
Available in
Beauty from Within
Toner
Lotion
Cream
Facial Oil
Sheet Mask
Sunscreen
Recommended Formulation
StanYouth CR3
Skin Cellular Rejuvenation:
Fisetin clears senescent cells, urolithin A repairs cellular rhythm, and L-ergothioneine strengthens internal defenses (patent has been applied).
Nicotinamide (Niacinamide)
Skin Resilience:
Cellular energy and DNA repair cofactors, enhancing SIRT1 activation for robust skin resilience.
Bakuchiol
Skin Rhythm:
Gentle circadian regulator that amplifies nighttime repair signals for synchronized skin renewal and rejuvenation.
Quality Assurance
NON-GMO
ISO 9001
Gluten Free
BSE Free
Halal Certified
Kosher Certified
HACCP
ISO 22000
Frequently asked questions
Does StanYouth have clinical data?
What is the production process for StanYouth Urolithin A? Is it extracted?
In which countries is Urolithin A currently available for use?
What is the water solubility of Urolithin A?
How stable is Urolithin A?
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