BeFisetin® Achieves Historic Milestone as World’s First SA-GRAS Certified Natural Fisetin

April 2, 2025 — Bonerge Lifescience is proud to announce a groundbreaking achievement in the longevity ingredient market: BeFisetin®, our premium fisetin formulation, has attained Self-affirmed Generally Recognized as Safe (SA-GRAS) status in the United States. This milestone establishes BeFisetin® as the world’s first all-natural fisetin ingredient to receive GRAS certification, reinforcing Bonerge’s leadership in scientifically validated, high-purity nutraceuticals.

Raising the Bar for Fisetin Quality & Safety

The global fisetin market has long been challenged by inconsistent quality standards, with many products failing to deliver on purity claims. While suppliers often advertise “98% HPLC” fisetin, independent testing reveals actual fisetin content as low as 75–85%, alongside undisclosed impurities—particularly concerning given fisetin’s extraction from inedible Anacardiaceae plants, which may retain toxic residues.

BeFisetin® disrupts this status quo by setting an uncompromising gold standard:

• SA-GRAS Certification: Rigorous safety evaluation for dietary supplement use.

• Transparent Specifications: ≥98% HPLC-verified fisetin content, <1% total impurities.

• Clinical Backing: Completed a double-blind trial on skin health efficacy, with a second large-scale study (sleep/immune support) underway.

Why SA-GRAS Matters for the Longevity Industry

GRAS certification is a transformative step for fisetin, transitioning it from an unregulated botanical to a clinically trusted, globally compliant ingredient. By meeting stringent requirements—including GMP manufacturing, validated testing methods, and comprehensive safety data—BeFisetin® empowers brands to innovate with confidence in anti-aging formulations.

“ SA-GRAS certification reflects our commitment to science and safety. BeFisetin® isn’t just an ingredient—it’s a foundation for trustworthy longevity solutions.”

Gloria, Bonerge Product Manager

Looking Ahead: A New Era for Senotherapeutics

This achievement marks the beginning of Bonerge’s mission to elevate industry standards. As demand for senolytic compounds grows, BeFisetin® stands at the forefront, offering:

• Regulatory readiness for global markets.

• Clinically substantiated anti-aging benefits.

• Unmatched purity, enabling premium product development.

For brands seeking a safe, efficacious, and scalable fisetin ingredient, BeFisetin® delivers unparalleled value.

For partnership inquiries or to learn more about BeFisetin®, please contact us.