BeFisetin® at Vitafoods Europe 2025 | Beauty from Within & Women’s Health-BONERGE

BeFisetin® at Vitafoods Europe 2025: Unlocking Beauty from Within for Women’s Health & Longevity

Time：May 26, 2025

Summary

At Vitafoods Europe 2025, "Beauty from Within" emerged as a key trend shaping the future of women's wellness. BeFisetin® gained strong attention as a natural senolytic ingredient aligned with this shift.

Key highlights include:
● Rapid growth of hair, skin & nail supplements in Europe
● Rising focus on ovarian health and female longevity
● Scientific evidence supporting fisetin’s role in skin, hair, and reproductive health

From May 20–23, 2025, the global nutraceutical community gathered in Barcelona for Vitafoods Europe, one of the industry's most influential annual events. This year, the spotlight shone brightly on the theme of “Beauty from Within”, reflecting a growing demand for inner health solutions driven by rising awareness of women’s wellness and longevity.

Among the standout ingredients was BeFisetin®, the flagship product by Bonerge Lifescience. As a potent senolytic and antioxidant compound, fisetin garnered significant interest for its multi-faceted benefits in skin health, ovarian function, and hair rejuvenation, firmly aligning with the "Beauty from Within" philosophy.

Women’s Health Drives Growth in Supplement Categories

In an interview with Vitafoods Insights, Innova market analyst Solène Limongi noted that the European supplement market showed healthy growth, with an overall increase of 4% from 2020 to 2024. While most subcategories expanded during this period, hair, skin, and nail supplements experienced the strongest growth, with new product launches rising at a compound annual growth rate (CAGR) of 24%, making it the fastest-growing segment[1].

Hair, Skin & Nails Supplements Lead

Hair, skin, and nail supplements were the fastest-growing subcategory in Europe between 2020 and 2024. In terms of new product launches, Slovakia (+51%) and France (+44%) showed the strongest growth.Capsules accounted for 32% of new formats, followed by powders (26%) and tablets (13%).

“ Capsules are likely favored for their convenience, neutral taste, and perceived efficacy. ” ^[1]
As Innova analyst Solène Limongi explained in a Vitafoods Insights interview

Ovarian Health Gains Attention

With premature ovarian insufficiency (POI) affecting 1%–3% of reproductive-age women in Europe, the global POI treatment market is projected to grow from $715M (2023) to $1.318B (2032) at a 6.9% CAGR, reflecting increased awareness and innovation.

BeFisetin®: A Natural Senolytic Targeting Skin, Hair, and Ovarian Health

1. Skin Rejuvenation

Senolytic clearance of dermal senescent cells: Fisetin selectively removes ~66% of senescent dermal fibroblasts without harming healthy cells, reducing SASP secretion and expression of aging markers (SA-β-Gal, p16, p53)[2].

Boosts collagen synthesis: By downregulating matrix metalloproteinases (MMP-1, MMP-3), fisetin helps preserve collagen and elastin, improving skin elasticity by up to 41.2% in mice[2].

Antioxidant and anti-inflammatory effects: Fisetin outperforms vitamin C in ROS scavenging, mitigates UV-induced damage, and suppresses inflammatory pathways like NF-κB and MAPK[3].

2. Hair Growth and Scalp Health

Activates hair follicle stem cells (HFSCs): Fisetin upregulates telomerase reverse transcriptase (TERT), a key enzyme in cellular regeneration. This promotes HFSC proliferation and drives follicles from the resting (telogen) phase into the active growth (anagen) phase[4].

Inhibits 5α-reductase Type 1: By suppressing this enzyme, fisetin reduces the conversion of testosterone into dihydrotestosterone (DHT)—a hormone that shrinks follicles and contributes to androgenetic alopecia[5].

Enhances scalp microcirculation and reduces inflammation: Fisetin improves mitochondrial activity in follicle cells and lowers pro-inflammatory cytokines like IL-6 and TNF-α, helping prevent premature follicle regression[4].

3. Ovarian Health Support

Delays ovarian aging and improves function: Fisetin combats oxidative stress, regulates hormone levels, reduces follicular apoptosis, and supports mitochondrial and epigenetic balance, showing improved fertility and hormone restoration in aged animal models[6].

Preserves post-ovulatory oocyte quality: Through Sirt1 pathway activation, fisetin enhances mitochondrial gene expression and suppresses ROS-induced damage and histone methylation anomalies[7].

Alleviates PCOS symptoms: Fisetin modulates AMPK and SIRT1, improves insulin sensitivity, balances LH/FSH ratios, and matches the efficacy of metformin in preclinical PCOS models[8].

A Future-Proof Ingredient for Holistic Anti-Aging and Female Wellness

Vitafoods Europe 2025 reflected a clear consumer pivot toward inner nourishment for outer beauty. With rising demand for wellness from within, beauty and women’s health are no longer separate concerns but part of a unified, proactive lifestyle.

BeFisetin® is emerging as a powerful, natural, multifunctional solution for skin, hair, and reproductive health—thanks to its scientifically backed senolytic, antioxidant, and anti-inflammatory properties. While further human studies are ongoing, its multi-targeted mechanism of action offers strong potential for next-generation strategies in natural anti-aging + reproductive protection.

References:
[1] Vitafoods Insights (2025) *Eyes on beauty: European hair, skin, and nail supplements experience 'remarkable' growth*, 16 May. Available at: https://www.vitafoodsinsights.com/nutricosmetics/eyes-on-beauty-european-hair-skin-and-nail-supplements-experience-remarkable-growth
[2] Kento Takaya,Toru Asou et al. Fisetin, a potential skin rejuvenation drug that eliminates senescent cells in the dermis. Biogerontology, 15 August 2023.
https://pubmed.ncbi.nlm.nih.gov/37736858/
[3]Tithi Roy, Sergette Banang-Mbeumi, et al. Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation. Front. Immunol., 18 January 2023.
https://pubmed.ncbi.nlm.nih.gov/36741386/
[4]Kubo C, et al. Fisetin Promotes Hair Growth by Augmenting TERT Expression. Frontiers in cell and developmental biology. 2020;8:566617.
https://pubmed.ncbi.nlm.nih.gov/33178686/
[5]Richard A. Hiipakka, et al. Structure±activity relationships for inhibition of human 5a-reductases by polyphenols.Biochemical Pharmacology 63 ,2002) 11.
https://pubmed.ncbi.nlm.nih.gov/11931850/
[6]Zhaoyu Yang, Jiaxuan Zhang, et al. Flavonoid Fisetin Alleviates Ovarian Aging of Laying Chickens by Enhancing Antioxidant Capacity and Glucose Metabolic Homeostasis. Antioxidants 2024, 13(12), 1432.
https://pubmed.ncbi.nlm.nih.gov/39765761/
[7]Xupeng Xing,Yalin Liang,et al. Fisetin Delays Postovulatory Oocyte Aging by Regulating Oxidative Stress and Mitochondrial Function through Sirt1 Pathway. Molecules. 2023 Jul 20; 28(14):5533.
https://pubmed.ncbi.nlm.nih.gov/37513404/
[8]Simerjeet Kaur Chahal, Atul Kabra.Fisetin ameliorates polycystic ovary syndrome in rats via a mechanistic modulation of AMP-activated protein kinase and SIRT1 molecular pathway. Naunyn Schmiedebergs Arch Pharmacol. 2024 Dec; 397(12):10017-10029.
https://pubmed.ncbi.nlm.nih.gov/38963551/