Patented Crystalline
Form of PQQ
(Pyrroloquinoline Quinone)
What is MitoSober® ?
MitoSober PQQ is manufactured by a GMP-certified pharmaceutical company, ensuring quality and consistency.
FDA GRAS Certified
As one of the earliest ingredients to receive FDA GRAS status in 2016, MitoSober PQQ has built a decade of proven safety.
Unique Crystalline Form Patent
Patent No. CN108026091B covers the crystalline forms I–IV of sodium PQQ and their preparation methods.
High Chromatographic Purity
Chromatographic purity near 100% ensures the safety of MitoSober PQQ.
High Solubility & Excellent Flowability
Ensures uniform PQQ content while reducing solid dosage volume for easier formulation, and supports water-soluble products with improved bioavailability and efficacy.
About PQQ
PQQ (pyrroloquinoline quinone) Disodium is an aromatic ortho-quinone compound naturally present in soil and in various foods, including spinach, kiwi, soybeans, and human breast milk.
Recognized as the third redox cofactor after NAD and FAD, PQQ plays a key role in mitochondrial biogenesis and cellular energy metabolism. Dietary insufficiency can lead to symptoms resembling vitamin deficiency.
Therefore human endogenous synthesis of PQQ is insufficient, necessitating additional intake from supplements or functional foods.
Health Benefits
Powerful
antioxidant support
PQQ increases the expression of PGC-1α, promotes mitochondrial biogenesis, enhances citrate synthase and cytochrome c oxidase activities, and reduces oxidative damage associated with mitochondrial dysfunction.
In cell studies, PQQ markedly lowers glucose-induced ROS elevations, restoring levels close to those of normal cells.
J Biol Chem. 2010 Jan 1;285(1):142-52.
Promotes new mitochondria growth
Studies show that PQQ stimulates mitochondrial biogenesis by activating PGC-1α and CREB.
After 24–48 h of PQQ treatment, citrate synthase and cytochrome c oxidase activities rise 20–40% and ~30%, mitochondrial mass increases 15–24%, mtDNA/nDNA ratio ~48%, and oxygen consumption 20–30%.
J Biol Chem. 2010 Jan 1;285(1):142-52.
Optimizes ovarian cellular energy
PQQ restored ovarian weight in POI mice, increased primordial (↑48%) and mature follicles (↑71%), and reduced atretic follicles; MSC‑Mito + PQQ was more effective.
Combined treatment raised AMH and E2, lowered FSH, boosted SOD, reduced MDA, and restored ATP, enhancing antioxidant capacity and mitochondrial function.
Stem Cell Res Ther 15, 97 (2024).
Supports
cognition & memory
Pre-treating BV2 microglia with PQQ (0.1–10 μM) dose-dependently reduced rotenone-induced inflammation.
At 10μM, PQQ lowered pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) by ~50% and decreased NO production by ~40%, alleviating neuroinflammation.
Molecules. 2020 Sep 23;25(19):4359.
PQQ increases the expression of PGC-1α, promotes mitochondrial biogenesis, enhances citrate synthase and cytochrome c oxidase activities, and reduces oxidative damage associated with mitochondrial dysfunction.
In cell studies, PQQ markedly lowers glucose-induced ROS elevations, restoring levels close to those of normal cells.
J Biol Chem. 2010 Jan 1;285(1):142-52.
Studies show that PQQ stimulates mitochondrial biogenesis by activating PGC-1α and CREB.
After 24–48 h of PQQ treatment, citrate synthase and cytochrome c oxidase activities rise 20–40% and ~30%, mitochondrial mass increases 15–24%, mtDNA/nDNA ratio ~48%, and oxygen consumption 20–30%.
J Biol Chem. 2010 Jan 1;285(1):142-52.
PQQ restored ovarian weight in POI mice, increased primordial (↑48%) and mature follicles (↑71%), and reduced atretic follicles; MSC‑Mito + PQQ was more effective.
Combined treatment raised AMH and E2, lowered FSH, boosted SOD, reduced MDA, and restored ATP, enhancing antioxidant capacity and mitochondrial function.
Stem Cell Res Ther 15, 97 (2024).
Pre-treating BV2 microglia with PQQ (0.1–10 μM) dose-dependently reduced rotenone-induced inflammation.
At 10μM, PQQ lowered pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) by ~50% and decreased NO production by ~40%, alleviating neuroinflammation.
Molecules. 2020 Sep 23;25(19):4359.
Clinical Summary
Effects of PQQ Supplementation on Indices of Mitochondrial Biogenesis in Untrained Men
Enrolled: 23 apparently healthy, non-endurance trained males
Dosage: 20 mg/day PQQ
Control Group: 20 mg/day cellulose PLC
Trial Cycle: 6 Weeks
Detection Indicators: Body composition testing, Peak oxygen consumption exercise sessions, Skeletal muscle cellular extraction, Muscle protein quantification, Skeletal muscle marker of mitochondrial biogenesis
Result: The PQQ group had a significant increase in PGC-1α protein (a biochemical marker for mitochondrial biogenesis) levels from baseline to post endurance training compared to PLC (p < 0.05). Furthermore, the PQQ group had higher PGC-1α protein levels after 6 weeks of endurance training compared to PLC (p < 0.05).
DOI: 1.10.1080/07315724.2019.1705203（PureQQ）
The Impact of PQQ Disodium Salt Supplementation on Brain Function Across Age Groups
Enrolled: Adults aged 20-65 years
Dosage: 20 mg/day PQQ
Control Group: Placebo
Trial Cycle: 12 Weeks
Detection Indicators: Safety, Cognitive test
Result: In younger adults (aged 20–40 years), PQQ improved cognitive function (cognitive flexibility, processing speed, and execution speed) after 8 weeks. Only older adults (aged 41–65 years) showed improvements in complex and verbal memory after 12 weeks.
DOI: 10.1039/d2fo01515c.
Efficacy and Safety of a Novel PQQ Disodium Supplement on Muscle Strength and Physical Function
Enrolled: 64 healthy Japanese adults aged 20-75 years
Dosage: 21.5 mg/day PQQ
Control Group: Placebo
Trial Cycle: 16 Weeks
Detection Indicators: Lower limb extensor strength, 10m shuttle walking, 6-minute walking test, Grip strength, 10m walking test
Result: Significant improvements were observed in lower limb extension muscle strength and grip strength in PQQ group (p<0.01). Meanwhile, the physical function results of the 10-meter shuttle walking, 6-minutes walking, and 10-meter walking tests were also significantly improved in PQQ group (p<0.01).
DOI: 10.1016/j.jff.2024.106012（mnemoPQQ）
Effects of Oral Supplementation with PQQ on Stress, Fatigue, and Sleep
Enrolled: Adults with a diagnosed sleep disorder or complaint and fatigue
Dosage: 20 mg/day PQQ
Control Group: Placebo
Trial Cycle: 8 Weeks
Detection Indicators: Four methods of subjective self-reporting, Cortisol awakening response,
Result: POQ supplementation seems associated with improved sleep quality and duration. Mood was also improved by diminishing feelings of fatigue, and improved quality of life (QOL) on measures of appetite, sleep, pain and obsession.
DOI: 10.31989/ffhd.v2i8.81（BioPQQ）
Available in
Tablets
Hard Capsule
Soft Capsule
Powders
Beverages
Gummies
Liquids
Recommended Formulation
S-Equol
Ovarian Health:
PQQ can enhance the ATP level and ovarian vitality by promoting the biogenesis of mitochondria, and S-equol can modulate ovarian function via Estrogen-like effect.
CoQ10
Mitochondrial Function:
PQQ can promote the biogenesis of mitochondria, while CoQ10 can maintain the operation of mitochondria.
Urolithin A
NAD+ Support:
PQQ can promote the biogenesis of mitochondria, and urolithin A can active SIRT1-NAMPT pathway to improve the production of NAD+.
Quality Assurance
NON GMO
ISO 9001
Gluten Free
BSE Free
Halal Certified
Kosher Certified
HACCP
ISO 22000
Frequently asked questions
What is the most significant health benefit of MitoSober PQQ?
Is it fermented or synthesized?
What regulatory certifications has MitoSober obtained?
What patent backing does MitoSober have?
In which countries can PQQ be used?
Recommend Products
RequestSample
Leave Word
Have further questions? Our friendly experts will get back to you within 24 hours to assist you further
+1(425)866-9043
sales@bonerge.com