Bonerge-Featured Ingredients-Best fisetin supplement from China manufacturer

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BeFisetin® Fisetin

Be The Golden Standard of Fisetin

· Fisetin is naturally present in many plants, fuits and vegetables in trace amounts, including phyllanthus emblica, strawberries, apples, persimmon, and mulberry fruits and leaves etc.

· Strawberries are a known fruit source that contains the highest amount of Fisetin. 625 gram of Strawberries can provide us 100mg Fisetin.

· BeFisetin is the first SA-GRAS approved Fisetin ingredients.

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Product Brief

Scientific Researches

Why Choose

Our Research

Newest fisetin benefits customized

Product Brief

Fisetin is getting a lot of attention because of its senolytic properties, according to the research. A senolytic is a class of small molecules that can induce the death of senescent cells and promote human health.

Mechanism and Scientific Research of Fisetin:

· Promote the Apoptosis of Senescent Cells

· Reduce SASP and Chronic Inflammation

· Delay the Inflammaging of the Organism

· Promote Hair Regeneration

· Relieve the Aging Process

· Emotional Well-being Promotion

Scientific Researches

Regulate Senescent cells, Strengthen Immune Function

Cellular senescence is closely linked to the body's immune function. Regulating the number of senescent cells may be an effective way to ease the burden on the immune system and enhance immune function.

Since 2018, several prominent research teams have discovered that fisetin regulates the number of senescent cells through two mechanisms: inhibiting their formation and clearing excessive ones. The research has demonstrated that fisetin is the most potent botanical senolytic among 11 natural compounds.

Medical Science, 50(06), 685-692.

Prevent Hair Loss and Promote Hair Regeneration

On the one hand, Fisetin, as a 5α-reductase inhibitor, can effectively block hair loss caused by dihydrotestosterone, and this mechanism is consistent with that of dutasteride.

On the other hand, Fisetin induces the proliferation of hair follicle stem cells and activates hair follicles by enhancing the activity of telomerase reverse transcriptase (TERT), ultimately achieving the effect of promoting hair growth.

Biochemical pharmacology, 63(6), 1165-1176. / Nutrients, 13(6), 2087.

Relieve the Skin-aging Process and Inflammation

Accumulated senescent fibroblasts in the skin induce extracellular matrix (ECM) dysfunction by secreting SASP. This leads to skin aging.

A research conducted by Keio University in Japan found that fisetin can selectively eliminate more than 60% of senescent dermal fibroblasts, inhibit the secretion of SASP, and increase collagen production. Thus to improve skin condition and delay skin aging.

Biogerontology, 25(1), 161-175.

Emotional Well-being Promotion

Fisetin can cross the blood-brain barrier (BBB), which effectively reduces inflammatory factors and markers of aging in the brain, relieves stress, and enhances mood and cognitive health while significantly restoring dopamine levels (increasing dopamine levels 2.2x).

Journal of dietary supplements, 18(1), 57–71.

Why Choose

BeFisetin

BeFisetin® is the brand name for premium Fisetin developed by Bonerge following compendial guidelines.

Affirmed GRAS & 100% Botanical

· BeFisetin stands as the premier Fisetin ingredient with Self-Affirmed GRAS status.

· We perform C14 testing to guarantee that BeFisetin is composed of 100% Biobased Carbon, signifying that its origin is wholly derived from plants.

· There is a prevalence of synthetic Fisetin in the market, which is erroneously purported to be natural Fisetin.

Ultra Pure and Safe

· Anacardiaceae plants are the main source of plant lacquer. Many low-quality fisetin products in the market have lacquer impurities.

· BeFisetin has removed all black impurities, reaching a high standard: Botanical flavones ≥ 99%, Fisetin ≥ 98%, and Total impurities ＜ 1%.

· BeFisetin is free of Oil Paint and Wax, ensuring its safety.

Tested with Top Reference Standard (RS)

· Many Fisetin Products on the market are labeled as 98%, yet the actual Fisetin content remains uncertain as the Purity testing is often deceptive.

· A reliable RS sample serves as an unbiased judge and plays a crucial role in ensuring the accuracy of assay testing.

· BeFisetin is examined by a reputable RS, thereby guaranteeing its accuracy and authenticity.

Sustainable and Eco-friendly

· We possess an exclusive Cotinus coggygria planting base, guaranteeing a stable supply and promoting sustainability.

· BeFisetin is produced through a continuous countercurrent extraction line, conserving energy and solvent while minimizing waste.

· BeFisetin is extracted using clean water, without the application of harmful chemicals such as methanol.

Our Research

Enhanced Bioavailability:

· Water Soluble Fisetin: 5% Fisetin, 100% water soluble

· Oil Soluble Fisetin: 3% Fisetin, 100% oil soluble

Clinical Research:

1.The Impact of Fisetin Supplementation on Skin Health

· Dosage: 500mg Fisetin

· Control Group: 500mg placebo

· Trial Cycle: 56 Days

· Detection Indicators: Skin heme, Skin inflammation, Transepidermal water loss, Wrinkle volume, Wrinkle photography, Skin elasticity, Skin firmness, Skin melanin, Skin color , etc.

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Disclaimer *

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. All information is provided solely for business-to-business customers with the aim of imparting general knowledge and is not intended for end-use consumers.

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+1 (949) 712-7328

sales@bonerge.com

Ontario CA 91761, USA

Changsha, Hunan, China

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