Fisetin vs quercetin
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Fisetin is naturally present in many plants, fuits and vegetables in trace amounts, including phyllanthus emblica, strawberries, apples, persimmon, and mulberry fruits and leaves etc.<br> Strawberries are a known fruit source that contains the highest amount of Fisetin. 625 gram of Strawberries can provide us 100mg Fisetin. <br> BeFisetin is the first SA-GRAS approved Fisetin ingredients.
Psoriasis is a chronic autoimmune skin disease, and fisetin effectively treats its symptoms by inhibiting the Akt/mTOR pathway, promoting keratinocyte differentiation, and enhancing autophagy. Topical fisetin outperforms rapamycin in improving clinical signs like erythema, scaling, swelling, and epidermal thickness, while histologically reducing epidermal thickness, immune cell infiltration, and rete ridges more effectively.
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Fisetin effectively selectively eliminates senescent dermal fibroblasts with a clearance rate of 66% and inhibits the secretion of SASP, thereby improving skin condition and slowing down the aging process. Additionally, fisetin was found to increase collagen density by 41.2%, contributing to skin rejuvenation.
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