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GlucoSober™ Dihydroberberine

The New Crystal Granule of Dihydroberberine


· Dihydroberberine (DHB), which represents a bioactive form of berberine (BBR), occurs naturally within certain plants, including Coptis chinensis, Phellodendron amurense, etc.

· GlucoSoberTM represents the pioneering crystalline form of dihydroberberine. It effectively addresses the long-standing application challenges associated with dihydroberberine, including problems such as instability, low density, poor fluidity and high static electricity.

GlucoSober™ Dihydroberberine
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  • GlucoSober™ Dihydroberberine

Product Brief

With the surging demand for berberine in the weight management market, dihydroberberine has attracted increasing attention and favor from more brands due to its higher bioavailability. As it is more easily absorbed into the bloodstream than berberine, dihydroberberine shows better application prospects in aspects such as visceral fat.

 

Scientific Research of Dihydroberberine:

· Appetite Regulation

· Reduce Visceral Fat

· Maintain Cardiovascular Health

· Regulate Intestinal Homeostasis

Scientific Researches

Reduce Visceral Fat More Effectively

Reduce Visceral Fat More Effectively

In mice fed an HFD (high fat diet), treatment with DHB (100 mg/kg/day) markedly reduced adiposity (epididymal fat, muscle fat, liver fat), compared with HFD controls. At the same dose, BBR had no effect on adiposity.

 

Diabetes, 57(5), 1414–1418.

Maintain Cardiovascular Health

Maintain Cardiovascular Health

The in vivo study evaluated the arterial health effects of BBR and DHB. The result showed that DHB reduced the plaque area in mouse arteries by 44.4% and helped improve plaque stability when compared with the control group. While BBR at the same dosage did not show a beneficial effect.

 

Journal of translational medicine, 12, 326.

Regulate Intestinal Homeostasis

Regulate Intestinal Homeostasis

The goblet cells produce and secrete mucus to maintain the colon mucosal barrier. In vitro studies showed that the loss of goblet cells caused by DSS were significantly reversed by DHB, and AZA (a commonly used drug for colitis) groups. The effect of DHB (at a dose of 50 mg/kg) is much better than that of BBR and comparable to that of a 13 mg/kg dose of AZA.

 

Phytomedicine : international journal of phytotherapy and phytopharmacology, 90, 153631.

Why Choose

GlucoSober

As a reduced form of berberine, dihydroberberine shows stronger bioactivity but is susceptible to degradation, undermining product stability and efficacy. Commercially available variants also present issues like low bulk density (< 0.3 g/ml), poor flowabi
More Stable in Quality, More Guranteed in Efficacy

More Stable in Quality, More Guranteed in Efficacy

· Dihydroberberine will degrade under conditions such as high temperature, and contact with water.

 

· GlucoSober employs patented technology. Its unique crystal form is more stable and less likely to degrade.

 

More Excellent Bulk Density and Flowability

More Excellent Bulk Density and Flowability

· Some DHB powder on the market is prone to moisture absorption and caking, has poor fluidity and low bulk density (<0.3 g/ml), not conducive to encapsulation and tableting. 

 

· GlucoSober's crystal particle have a bulk density >0.5 g/ml, excellent fluidity, don't absorb moisture or cake when exposed to air.

 

More Credible With German Reference Standard

More Credible With German Reference Standard

· There is no official USP standard for DHB. GlucoSober is the first to adopt the RS of Phytolab in Germany, thereby making the test results more accurate and trustworthy.

 

 

Our Research

 

Enhanced Bioavailability:

1. Rat bioavailability assay: GlucoSober 54 times more bioavailable than Berberine

· Dosage: 200mg/kg Dihyfroberberine (DHB)

· Control Group: 200mg/kg Berberine HCL (BBR)

· Result

         Cmax (DHB) : 167.039 ng/mL  [Cmax (BBR) : 8.738 ng/mL]

         AUC (DHB) : 141548.516 ng/mL*min  [AUC (BBR) : 2614.21 ng/mL*min]

 

 

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Disclaimer *

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. All information is provided solely for business-to-business customers with the aim of imparting general knowledge and is not intended for end-use consumers.