EGT inhibited significantly the production of melanin and the activity of tyrosinase in a dose dependent manner when compared to the control group (with α-MSH). Although the inhibiting effect of 0.1 mM EGT was weaker than 0.1 mM VC, further increase of VC concentration showed strong cytotoxic. This may be due to the difference in safety and effective concentration of both. Inhibition of melanin production and tyrosinase activity in B16–F10 melanocytes were achieved by complete elimination of α-MSH in the presence of 10 mM EGT.

Biochemical and biophysical research communications, 682, 163-173.

UVA can penetrate into the dermis, destroy and decompose human collagen, cause aging and aging of the skin, and lead to rough skin, pigmentation and skin cancer. UVB acts on the surface of the skin, reduces cell activity, and causes sunburn and skin blackening for a long time. EGT has effects of relieving photoaging in UVB-induced skin damage and that these effects are mediated by suppressing the generation of ROS and pro-inflammatory cytokines and inhibiting apoptosis of keratinocytes, and by suppressing the modification to collagen homeostasis in fibroblasts.

Oxidative medicine and cellular longevity, 2020, 2576823.

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