Fisetin Supplement
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Fisetin is naturally present in many plants, fuits and vegetables in trace amounts, including phyllanthus emblica, strawberries, apples, persimmon, and mulberry fruits and leaves etc.<br> Strawberries are a known fruit source that contains the highest amount of Fisetin. 625 gram of Strawberries can provide us 100mg Fisetin. <br> BeFisetin is the first SA-GRAS approved Fisetin ingredients.
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UA can reduce senescence phenotype in skin fiber cells, inhibit β-galactosidase activity and extracellular matrix decomposition. It also shows potential in modulating the expression of various genes and proteins related to skin aging, such as those involved in collagen synthesis and turnover. Thus helps to enhance the firmness and elasticity of the skin, reducing the appearance of wrinkles and fine lines.
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Photoaging is one of the culprits for age-related skin deterioration. Urolithin A can diminish the senescent phenotype in skin fibroblasts caused by UVA, decrease the accumulation of intracellular ROS, and activate antioxidant enzymes. The human fibroblast experiment showed that using just a concentration of 0.1 μM of urolithin A can reduce approximately 50% of UVA-induced senescent phenotypes.
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