Salidroside can dose-dependently improve cognitive function and reduce Aβ plaque accumulation in SAMP8 mice. It mitigated neuronal damage, oxidative stress, and inflammation while enhancing mitochondrial and metabolic functions. Salidroside regulated iron homeostasis, decreased TFR1 and ACSL4 expression, and activated the Nrf2/GPX4 pathway by upregulating SLC7A11 and GPX4.

Phytomedicine : international journal of phytotherapy and phytopharmacology, 114, 154762.

Proper nutrition is essential for optimal physical and mental performance, and overall well-being of active individuals. A randomized, double-blind study showed that salidroside can help to enhance overall percent predicted oxygen uptake during high-intensity intermittent exercise and reduce exercise-induced muscle damage.

In addition, salidroside group also exhibited stable mood states and maintained performance levels during the time-to-exhaustion test.

Journal of the International Society of Sports Nutrition, 21(1), 2433744.

The ATP citrate lyase gene (Acly) encodes a key enzyme for cholesterol and fatty acid synthesis. Studies have shown that salidroside significantly inhibits the synthesis of lipids such as cholesterol and fatty acids in the liver of mice fed with high-fat diet by down-regulating the expression of sterol regulatory element binding proteins (Srebf1 and Srebf2). At the same time, salidroside can specifically reduce the expression of Acly gene, which may be an important mechanism of its regulation of lipid metabolism.

Biomedicine & pharmacotherapy, 134, 111137.

· Bonerge's Salidroside is manufactured through a synthetic biotechnology platform, enabling large-scale production that overcomes the limitations associated with traditional plant extraction methods. This advanced production technology ensures a consistent and reliable supply chain, independent of seasonal variations and geographical constraints of raw material availability, thereby guaranteeing long-term stable production capacity to meet market demands.