Why do we say it's important to get rid of senescent cells?

What defines a senescent cell?

Senescence is a cellular response characterized by a stable and long-term loss of growth potential and other phenotypic alterations, particularly the development of a proinflammatory secretome.

Hayflick first reported the limit of proliferation and division of human fibroblasts cultured in vitro [1], that is the Hayflick limit (Figure 1), which first drew attention to the limit of cell lifespan. This discovery aroused the enthusiasm of researchers to explore the mystery of life and new strategies for anti-aging. Since then, more and more research has been conducted on cellular senescence.